|
KMID : 1098420160240010001
|
|
Korean Journal of Medicinal Crop Science
2016 Volume.24 No. 1 p.1 ~ p.6
|
|
|
Effect of Dendrobium speciosum Var. Aqueous Extract on Loperamide-Induced Constipation in Rats
|
|
Jang Ji-Hun
Jung Ho-Kyung
Sim Mi-Ok
An Byeong-Kwan
Kim Min-Suk
Kang Byoung-Man
Cho Jung-Hee
Bean Chul-Gu
Kim Seong-Cheol
Jung Won-Seok
|
|
|
Abstract
|
|
|
Background : Irregular meals and insufficient exercise are major modern lifestyle-related risk factors for constipation. This study aimed to examine the effects of the aqueous extract of Dendrobium speciosum var. (DM) on the improvement of intestinal function and prevention of constipation in rats.
Methods and Results : Constipation in rat was induced by loperamide (4 ㎎/㎏) injection for 5 days and rats were randomly assigned to the following groups: normal control rats (NOR), constipated rats (LOP induced) and constipated rats supplemented with dulcolax-S (POS), DMSG, 100 ㎎/㎏ (DMSG-100), 300 ㎎/㎏ (DMSG-300) and 500 ㎎/㎏ (DMSG-500). The DMSG groups showed increments in the frequency and amount of stools compared to the LOP group. Loperamide treatment markedly reduced the water content of feces, whereas DMSG administration significantly increased fecal water contents. Moreover, DMSG improved intestinal transit speed in constipated-rats. Alcian blue staining revealed increased mucus production by crypt cells and mucus contents in feces and the mucosal surface.
Conclusions : In summary, DM extraction significantly improves intestinal function in rats, which indicates the effectiveness of this extract in the prevention and treatment of constipation.
|
|
|
KEYWORD
|
|
|
Dendrobium speciosum, Alcian Blue Staining, Constipation, Laxative, Loperamide
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|